BDBM50239395 CHEMBL4061302

SMILES OC(=O)CCN1C(=S)S\C(C1=O)=C1/C(=O)Nc2ccc(Cl)cc12

InChI Key InChIKey=VISHSGZPGQKEFX-UHFFFAOYSA-N

Data  2 IC50  6 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50239395   

TargetB-cell lymphoma 6 protein(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239395(CHEMBL4061302)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of GAL4 DNA binding domain fused BCL6 BTB domain (unknown origin) expressed in HEK 293T/17 cells after 24 hrs by Bright-Glo luciferase cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2019
Entry Details Article
PubMed
TargetB-cell lymphoma 6 protein(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239395(CHEMBL4061302)
Affinity DataIC50: 3.16E+4nMAssay Description:Inhibition of GAL4 DNA binding domain fused BCL6 BTB domain (unknown origin) expressed in HEK 293T/17 cells after 24 hrs by Bright-Glo luciferase cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2019
Entry Details Article
PubMed
TargetB-cell lymphoma 6 protein(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239395(CHEMBL4061302)
Affinity DataKd:  7.00E+3nMAssay Description:Binding affinity to recombinant RED-NHS labeled BCL6 BTB domain (unknown origin) expressed in Escherichia coli BL21 (DE3) after 10 mins by microscale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details Article
PubMed
TargetB-cell lymphoma 6 protein(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239395(CHEMBL4061302)
Affinity DataKd:  7.00E+3nMAssay Description:Binding affinity to recombinant RED-NHS labelled BCL6 BTB domain (1 to 129 residues) (unknown origin) after 10 mins by microscale thermophoresis meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2020
Entry Details Article
PubMed
TargetB-cell lymphoma 6 protein(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239395(CHEMBL4061302)
Affinity DataKd:  7.00E+3nMAssay Description:Binding affinity to fluorescently labeled recombinant BCL6 BTB domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetB-cell lymphoma 6 protein(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239395(CHEMBL4061302)
Affinity DataKd:  7.00E+3nMAssay Description:Binding affinity to recombinant BCL6 BTB domain (unknown origin) incubated for 10 mins by microscale thermophoresis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetB-cell lymphoma 6 protein(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239395(CHEMBL4061302)
Affinity DataKd:  7.88E+3nMAssay Description:Binding affinity to recombinant human C-terminal GST-tagged BCL6 BTB domain C8Q/C67R/C84N triple mutant expressed in Escherichia coli BL21 (DE3) cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetB-cell lymphoma 6 protein(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239395(CHEMBL4061302)
Affinity DataKd:  7.90E+3nMAssay Description:Binding affinity to human BCL6 BTP domain assessed as dissociation constant by biolayer interferometry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed