BDBM50239363 CHEMBL4094351

SMILES c1c2cc(c3c1CCC(=O)N3)OC/C=C/CO[C@H]4C[C@H](N(C4)c5cc(n6c(n5)c(cn6)C#N)N2)CO

InChI Key InChIKey=SABLEOBBNNRHAD-UHFFFAOYSA-N

Data  6 IC50  2 Kd

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50239363   

LigandPNGBDBM50239363(CHEMBL4094351)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of GAL4 DNA binding domain fused PLZF BTB domain (unknown origin) expressed in HEK 293T/17 cells after 24 hrs by Bright-Glo luciferase cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2019
Entry Details Article
PubMed
TargetB-cell lymphoma 6 protein(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239363(CHEMBL4094351)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of GAL4 DNA binding domain fused BCL6 BTB domain (unknown origin) expressed in HEK 293T/17 cells after 24 hrs by Bright-Glo luciferase cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239363(CHEMBL4094351)
Affinity DataKd:  6.5nMAssay Description:Binding affinity to Mcl1 (unknown origin) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetB-cell lymphoma 6 protein(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239363(CHEMBL4094351)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of Bcl6 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetB-cell lymphoma 6 protein(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239363(CHEMBL4094351)
Affinity DataKd:  6.5nMAssay Description:Binding affinity to human BCL6 BTP domain assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetB-cell lymphoma 6 protein(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239363(CHEMBL4094351)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human BCL6 BTP domain measured by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetB-cell lymphoma 6 protein(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239363(CHEMBL4094351)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human BCL6 BTP domain measured by cell reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase II subunit alpha 3(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50239363(CHEMBL4094351)
Affinity DataIC50: 640nMAssay Description:Inhibition of CK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMedPDB3D3D Structure (crystal)