BDBM50239124 CHEMBL4102511

SMILES CN(C)C(=O)c1cc([C@H]2CCCN2c2ccc(F)cc2)c2oc(cc(=O)c2c1)N1CCOCC1

InChI Key InChIKey=JJISBRLBXMGCRF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50239124   

LigandPNGBDBM50239124(CHEMBL4102511)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-468 cells assessed as decrease in AKT phosphorylation at Ser473 measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50239124(CHEMBL4102511)
Affinity DataIC50: 24nMAssay Description:Inhibition of recombinant human PI3Kalpha using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50239124(CHEMBL4102511)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of recombinant human PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50239124(CHEMBL4102511)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of recombinant human PI3Kdelta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50239124(CHEMBL4102511)
Affinity DataIC50: 330nMAssay Description:Inhibition of recombinant human PI3Kgamma using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed