BDBM50239055 CHEMBL4101047

SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(F)cc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F

InChI Key InChIKey=YZNSDAZKIRGCPR-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50239055   

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50239055(CHEMBL4101047)
Affinity DataIC50: 2.74E+3nMAssay Description:Inverse agonist activity at RORgammat in human Th17 cells assessed as inhibition of IL17A productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50239055(CHEMBL4101047)
Affinity DataIC50: 6.00E+3nMAssay Description:Inverse agonist activity at GAL4 DBD-fused human RORgammat expressed in HEK293T cells assessed as inhibition of transcriptional activity after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50239055(CHEMBL4101047)
Affinity DataKd:  6.60nMAssay Description:Displacement of 1,8-ANS from recombinant human RORgammat LBD expressed in Escherichia coli BL21 (DE3) cells assessed as inhibition of co-activator SR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed