BDBM50239051 CHEMBL4097051

SMILES COc1nc2ccc(cc2c(Cl)c1-c1cnc(nc1)C#N)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F

InChI Key InChIKey=ZNOWAPXQJXGMSS-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50239051   

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50239051(CHEMBL4097051)
Affinity DataIC50: 310nMAssay Description:Inverse agonist activity at GAL4 DBD-fused human RORgammat expressed in HEK293T cells assessed as inhibition of transcriptional activity after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50239051(CHEMBL4097051)
Affinity DataKd:  32nMAssay Description:Displacement of 1,8-ANS from recombinant human RORgammat LBD expressed in Escherichia coli BL21 (DE3) cells assessed as inhibition of co-activator SR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed