BDBM50238648 CHEMBL4102828

SMILES Cn1c(Cc2nn(C)c(=O)c3ccccc23)nnc1SCC(=O)Nc1ccc(Cl)cc1Cl

InChI Key InChIKey=RUZXXRYUPQCFAF-UHFFFAOYSA-N

Data  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50238648   

TargetInterleukin-2(Human)
University of Nantes

Curated by ChEMBL
LigandPNGBDBM50238648(CHEMBL4102828)
Affinity DataKd:  1.05E+4nMAssay Description:Binding affinity to recombinant human IL-2 by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details Article
PubMed
TargetInterleukin-15(Human)
University of Nantes

Curated by ChEMBL
LigandPNGBDBM50238648(CHEMBL4102828)
Affinity DataKd:  4.84E+4nMAssay Description:Binding affinity to recombinant human IL-15 by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details Article
PubMed
TargetInterleukin-15(Mouse)
University of Nantes

Curated by ChEMBL
LigandPNGBDBM50238648(CHEMBL4102828)
Affinity DataIC50: 2.25E+4nMAssay Description:Inhibition of IL-15 in mouse 32Dbeta cells assessed as decrease in cell growth in presence of RLI incubated for 30 mins followed by RLI addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetInterleukin-15(Mouse)
University of Nantes

Curated by ChEMBL
LigandPNGBDBM50238648(CHEMBL4102828)
Affinity DataIC50: 2.11E+4nMAssay Description:Inhibition of IL-15 in mouse 32Dbeta cells assessed as decrease in cell growth in presence of IL2 incubated for 30 mins followed by IL2 addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetInterleukin-15(Human)
University of Nantes

Curated by ChEMBL
LigandPNGBDBM50238648(CHEMBL4102828)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of IL-15-induced STAT3 phosphorylation in human NK92 cells incubated for 30 mins followed by IL-15 stimulation and measured after 1 hr by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetInterleukin-2(Human)
University of Nantes

Curated by ChEMBL
LigandPNGBDBM50238648(CHEMBL4102828)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of IL2-induced STAT3 phosphorylation in human NK92 cells incubated for 30 mins followed by IL-15 stimulation and measured after 1 hr by al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed