BDBM50238428 CHEMBL4087876

SMILES c1ccc2c(c1)nc(c3n2nnn3)Nc4ccc(cc4)C(=O)N5CCOCC5

InChI Key InChIKey=HWBRIQBWLONMBS-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50238428   

TargetPoly [ADP-ribose] polymerase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238428(CHEMBL4087876)
Affinity DataIC50: 5.01E+3nMAssay Description:Binding affinity to PARP1 in human Jurkat cell extract after 45 mins by mass spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238428(CHEMBL4087876)
Affinity DataIC50: 5.01E+3nMAssay Description:Binding affinity to PARP2 in human Jurkat cell extract after 45 mins by mass spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP11(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238428(CHEMBL4087876)
Affinity DataIC50: 5.01E+3nMAssay Description:Binding affinity to PARP11 in human Jurkat cell extract after 45 mins by mass spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238428(CHEMBL4087876)
Affinity DataIC50: 5.01E+3nMAssay Description:Binding affinity to PARP14 in human Jurkat cell extract after 45 mins by mass spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238428(CHEMBL4087876)
Affinity DataIC50: 5.01E+3nMAssay Description:Binding affinity to PARP16 in human Jurkat cell extract after 45 mins by mass spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238428(CHEMBL4087876)
Affinity DataIC50: 158nMAssay Description:Inhibition of TNKS1 (unknown origin) expressed in HEK293 cells co-expressing TCF/LEF luciferase plasmid assessed as reduction in wnt3a ligand-induced...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein mono-ADP-ribosyltransferase PARP4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238428(CHEMBL4087876)
Affinity DataIC50: 5.01E+3nMAssay Description:Binding affinity to PARP4 in human Jurkat cell extract after 45 mins by mass spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238428(CHEMBL4087876)
Affinity DataIC50: 50nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238428(CHEMBL4087876)
Affinity DataIC50: 5.01E+3nMAssay Description:Binding affinity to PARP10 in human Jurkat cell extract after 45 mins by mass spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed