BDBM50238272 CHEMBL4072731

SMILES Cc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4ccc(N5CCOCC5)c(C)c4)cc3)c12

InChI Key InChIKey=JJRJKCCMGSERLB-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50238272   

TargetMacrophage colony-stimulating factor 1 receptor(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50238272(CHEMBL4072731)
Affinity DataIC50: 160nMAssay Description:Inhibition of human full length His-tagged CSF1R expressed in baculovirus by Z'Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2019
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50238272(CHEMBL4072731)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of cKIT (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition in presence of ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2019
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50238272(CHEMBL4072731)
Affinity DataIC50: 159nMAssay Description:Inhibition of human GST-tagged FLT1 (781 to 1338 residues) expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2019
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50238272(CHEMBL4072731)
Affinity DataIC50: 2.28E+3nMAssay Description:Inhibition of VEGFR2 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition in presence of A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2019
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50238272(CHEMBL4072731)
Affinity DataIC50: 72nMAssay Description:Inhibition of human GST-tagged FLT4 (800 to 1297 residues) expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2019
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50238272(CHEMBL4072731)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2019
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50238272(CHEMBL4072731)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of PDGFRalpha (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2019
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50238272(CHEMBL4072731)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human GST-tagged RET (658 to 1114 residues) expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2019
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50238272(CHEMBL4072731)
Affinity DataIC50: 2nMAssay Description:Inhibition of human His-tagged FLT3 (564 to 958 residues) expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2019
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50238272(CHEMBL4072731)
Affinity DataIC50: 1nMAssay Description:Inhibition of human His-tagged PDGFRbeta (558 to 1106 residues) expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2019
Entry Details Article
PubMed