BDBM50238097 CHEMBL4075798

SMILES Cc1ccc(F)c(c1)-c1cc(Nc2ccnc3cn(CC(N)=O)nc23)c(C)cn1

InChI Key InChIKey=XVQAQEFIHMZUMY-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50238097   

TargetTGF-beta receptor type-1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50238097(CHEMBL4075798)
Affinity DataEC50:  251nMAssay Description:Inhibition of ALK5 in human Calu6 cells assessed as reduction in Smad2/3 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2019
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50238097(CHEMBL4075798)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant N-terminal GST tagged human ALK5 (200 to 503 residues) expressed in baculovirus expression system using FAM-NH2-KVLTQMGSPSI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2019
Entry Details Article
PubMed