BDBM50238080 CHEMBL4073422

SMILES Fc1ccc(Cl)cc1-c1cc(Nc2ccnc3cn[nH]c23)ccn1

InChI Key InChIKey=HOLSCRKUHSHXQY-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50238080   

TargetTGF-beta receptor type-1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50238080(CHEMBL4073422)
Affinity DataEC50:  50nMAssay Description:Inhibition of ALK5 (unknown origin) expressed in SBE-bla HEK293T cells assessed as decrease in TGFbeta1-induced Smad2/3 phosphorylation by beta lacta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2019
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50238080(CHEMBL4073422)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of recombinant N-terminal GST tagged human ALK5 (200 to 503 residues) expressed in baculovirus expression system using FAM-NH2-KVLTQMGSPSI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2019
Entry Details Article
PubMed