BDBM50237769 CHEMBL4064672

SMILES COC(=O)C1=C(CN2CCOC[C@H]2C(O)=O)NC(=N[C@H]1c1ccc(F)cc1Cl)c1nccs1

InChI Key InChIKey=QJLRUAVQNXTCMO-UHFFFAOYSA-N

Data  6 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50237769   

TargetCytochrome P450 3A4(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50237769(CHEMBL4064672)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50237769(CHEMBL4064672)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50237769(CHEMBL4064672)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2019
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50237769(CHEMBL4064672)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2019
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50237769(CHEMBL4064672)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2019
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Hec Pharma Group

Curated by ChEMBL
LigandPNGBDBM50237769(CHEMBL4064672)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by manual-patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetCapsid protein(HBV)
TBA

Curated by ChEMBL
LigandPNGBDBM50237769(CHEMBL4064672)
Affinity DataEC50:  3nMAssay Description:Inhibition of capsid in HBV infected in human HepG.2.2.15 cells assessed as reduction of HBV DNA incubated for 5 days by quantitative PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCapsid protein(HBV)
TBA

Curated by ChEMBL
LigandPNGBDBM50237769(CHEMBL4064672)
Affinity DataEC50:  3nMAssay Description:Inhibition of capsid in HBV infected in human HepG.2.2.15 cells assessed as reduction of HBV DNA incubated for 5 days by quantitative PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed