BDBM50237672 CHEMBL4089159

SMILES COC(=O)C1=C(Nc2ccccc2Cl)O\C(=C/c2c[nH]c3ncccc23)C1=O

InChI Key InChIKey=ASLGQVPNOSGBQR-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50237672   

TargetDual specificity protein kinase CLK2(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50237672(CHEMBL4089159)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of CLK2 (unknown origin) pretreated for 30 mins followed by substrate addition measured after 5 hrs in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2019
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK1(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50237672(CHEMBL4089159)
Affinity DataIC50: 5nMAssay Description:Inhibition of CLK1 (unknown origin) pretreated for 30 mins followed by substrate addition measured after 5 hrs in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2019
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50237672(CHEMBL4089159)
Affinity DataIC50: 37nMAssay Description:Inhibition of GSK3alpha (unknown origin) pretreated for 30 mins followed by substrate addition measured after 5 hrs in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2019
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50237672(CHEMBL4089159)
Affinity DataIC50: 51nMAssay Description:Inhibition of GSK3beta (unknown origin) pretreated for 30 mins followed by substrate addition measured after 5 hrs in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50237672(CHEMBL4089159)
Affinity DataIC50: 53nMAssay Description:Inhibition of DYRK1A (unknown origin) pretreated for 30 mins followed by substrate addition measured after 5 hrs in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50237672(CHEMBL4089159)
Affinity DataIC50: 77nMAssay Description:Inhibition of PIM1 (unknown origin) pretreated for 30 mins followed by substrate addition measured after 5 hrs in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50237672(CHEMBL4089159)
Affinity DataIC50: 278nMAssay Description:Inhibition of Erk1 (unknown origin) pretreated for 30 mins followed by substrate addition measured after 5 hrs in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50237672(CHEMBL4089159)
Affinity DataIC50: 191nMAssay Description:ATP competitive inhibition of recombinant human Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50237672(CHEMBL4089159)
Affinity DataIC50: 61nMAssay Description:Inhibition of Erk2 (unknown origin) pretreated for 30 mins followed by substrate addition measured after 5 hrs in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50237672(CHEMBL4089159)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant human Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus expression syst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2019
Entry Details Article
PubMed