BDBM50237588 CHEBI:31624::CHEMBL1057

SMILES Oc1ccc2c(Oc3cc(O)ccc3C22OC(=O)c3ccccc23)c1

InChI Key InChIKey=GNBHRKFJIUUOQI-UHFFFAOYSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50237588   

TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50237588(CHEMBL1057 | CHEBI:31624)
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50237588(CHEMBL1057 | CHEBI:31624)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50237588(CHEMBL1057 | CHEBI:31624)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50237588(CHEMBL1057 | CHEBI:31624)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50237588(CHEMBL1057 | CHEBI:31624)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50237588(CHEMBL1057 | CHEBI:31624)
Affinity DataIC50: 3.23E+3nMAssay Description:Inhibition of N-terminal 31 residues truncated FTO (unknown origin) demethylase activity using m6A containing ssRNA as substrate incubated for 1 hr b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetRNA demethylase ALKBH5(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50237588(CHEMBL1057 | CHEBI:31624)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ALKBH5 (66 to 292 residues) demethylase activity using 49 nt methylated ssDNA as substrate incubated for 2 hrs by GelRed staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
University of Nebraska

Curated by ChEMBL
LigandPNGBDBM50237588(CHEMBL1057 | CHEBI:31624)
Affinity DataEC50:  1.95E+4nMAssay Description:Activation of recombinant human ACE2 using McaAPK(Dnp)-OH as substrate preincubated for 15 mins followed by substrate addition spectra max Gemini M5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed