BDBM50237433 CHEMBL4063506

SMILES OC[C@H]1CCCN1Cc1ccc(COc2cccc(NC(=O)c3ccccc3)c2)cc1

InChI Key InChIKey=OHVIRCSJFFPEGC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50237433   

TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237433(CHEMBL4063506)
Affinity DataIC50: 3.67E+3nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in ADP formation using sphingosine as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237433(CHEMBL4063506)
Affinity DataIC50: 145nMAssay Description:Inhibition of SPHK2 (unknown origin) by FITC-based caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237433(CHEMBL4063506)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237433(CHEMBL4063506)
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of SPHK1 in human whole-blood using C17-sphingosine as substrate assessed as reduction in C17-S1P production preincubated for 30 mins foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237433(CHEMBL4063506)
Affinity DataIC50: 9.82E+3nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in S1P formation using sphingosine as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2019
Entry Details Article
PubMed