BDBM50236939 CHEMBL2333945

SMILES c1ccc(cc1)C(=O)NNC(=O)c2ccc(cc2)CNS(=O)(=O)c3ccc(c(c3)Cl)F

InChI Key InChIKey=FYIBXBFDXNPBSF-UHFFFAOYSA-N

Data  12 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50236939   

Target1,3-beta-glucan synthase(Yeast)
University of M£Nster

Curated by ChEMBL
LigandPNGBDBM50236939(CHEMBL2333945)
Affinity DataIC50: 109nMAssay Description:Negative allosteric modulation of eGFP-fused human GluN2A receptor expressed in HEK293T cells assessed as inhibition of NMDA-induced channel current ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2019
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of M£Nster

Curated by ChEMBL
LigandPNGBDBM50236939(CHEMBL2333945)
Affinity DataIC50: 512nMAssay Description:Antagonist activity at rat GluN1A/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced channel cur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 2C(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50236939(CHEMBL2333945)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of human GluN2C receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced channel cur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
University of M£Nster

Curated by ChEMBL
LigandPNGBDBM50236939(CHEMBL2333945)
Affinity DataIC50: 340nMAssay Description:Negative allosteric modulation of human GluN2A receptor expressed in HEK cells assessed as reduction in 3 uM glycine/glutamate-induced intracellular ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50236939(CHEMBL2333945)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of human GluN2B receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced channel cur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
University of M£Nster

Curated by ChEMBL
LigandPNGBDBM50236939(CHEMBL2333945)
Affinity DataIC50: 320nMAssay Description:Negative allosteric modulation of human GluN2A receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced channel cur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50236939(CHEMBL2333945)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN2B receptor expressed in HEK cells assessed as reduction in glycine/glutamate-induced intracellular calci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50236939(CHEMBL2333945)
Affinity DataIC50: 446nMAssay Description:Negative allosteric modulation of human GluN1/GluN2A receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced chann...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 2D(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50236939(CHEMBL2333945)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of human GluN2D receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced channel cur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50236939(CHEMBL2333945)
Affinity DataIC50: 3.00E+4nMAssay Description:Negative allosteric modulation of human GluN2D receptor expressed in HEK cells assessed as reduction in glycine/glutamate-induced intracellular calci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
University of M£Nster

Curated by ChEMBL
LigandPNGBDBM50236939(CHEMBL2333945)
Affinity DataIC50: 110nMAssay Description:Negative allosteric modulation of human GluN2A receptor expressed in HEK cells assessed as reduction in glycine/glutamate-induced intracellular calci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of M£Nster

Curated by ChEMBL
LigandPNGBDBM50236939(CHEMBL2333945)
Affinity DataIC50: 170nMAssay Description:Negative allosteric modulation of recombinant rat GluN1/GluN2A expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)