BDBM50236856 CHEMBL272198::N-cyclopropyl-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide::N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide

SMILES COc1cc2c(ccnc2cc1OC)Oc3ccc4c(c3)cccc4C(=O)NC5CC5

InChI Key InChIKey=ZATGFXTWDKIEKC-UHFFFAOYSA-N

Data  12 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50236856   

TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236856(N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]n...)
Affinity DataIC50: 118nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50236856(N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]n...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236856(N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]n...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236856(N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]n...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of c-MetMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236856(N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]n...)
Affinity DataIC50: 330nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236856(N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]n...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236856(N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]n...)
Affinity DataIC50: 466nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236856(N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]n...)
Affinity DataIC50: 396nMAssay Description:Inhibition of FGRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236856(N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]n...)
Affinity DataIC50: 27nMAssay Description:Inhibition of LynMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50236856(N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]n...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50236856(N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]n...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50236856(N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]n...)
Affinity DataIC50: 0.603nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)