BDBM50236598 CHEMBL4099382

SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)N[C@@H]2CCOC[C@@H]2C(=O)NO)c2ccccc2n1

InChI Key InChIKey=RGOBJMXLMSLVGN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50236598   

LigandPNGBDBM50236598(CHEMBL4099382)
Affinity DataIC50: 17nMAssay Description:Inhibition of TACE in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated TNFalpha production pretreated for 1 hr followed by LPS stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50236598(CHEMBL4099382)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of recombinant TACE catalytic domain (unknown origin) using Abz-LAQAVRSSSR-Dpa as substrate preincubated for 10 mins followed by substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50236598(CHEMBL4099382)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant TACE catalytic domain (unknown origin) using Abz-LAQAVRSSSR-Dpa as substrate preincubated for 10 mins followed by substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50236598(CHEMBL4099382)
Affinity DataIC50: 16nMAssay Description:Inhibition of TACE in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated TNFalpha production pretreated for 1 hr followed by LPS stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed