BDBM50236389 CHEMBL273208::N-methyl(6-methyl-4-(2-phenoxyphenoxy)pyridin-3-yl)methanamine::N-methyl-1-(6-methyl-4-(2-phenoxyphenoxy)pyridin-3-yl)methanamine

SMILES CNCc1cnc(C)cc1Oc1ccccc1Oc1ccccc1

InChI Key InChIKey=AIBJZSMLYKTKIK-UHFFFAOYSA-N

Data  7 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50236389   

TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50236389(N-methyl-1-(6-methyl-4-(2-phenoxyphenoxy)pyridin-3...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50236389(N-methyl-1-(6-methyl-4-(2-phenoxyphenoxy)pyridin-3...)
Affinity DataIC50: 1.12E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50236389(N-methyl-1-(6-methyl-4-(2-phenoxyphenoxy)pyridin-3...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50236389(N-methyl-1-(6-methyl-4-(2-phenoxyphenoxy)pyridin-3...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50236389(N-methyl-1-(6-methyl-4-(2-phenoxyphenoxy)pyridin-3...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50236389(N-methyl-1-(6-methyl-4-(2-phenoxyphenoxy)pyridin-3...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50236389(N-methyl-1-(6-methyl-4-(2-phenoxyphenoxy)pyridin-3...)
Affinity DataKi:  10nMAssay Description:Inhibition of [3H]Nisoxetine uptake in human noradrenaline transporter transfected HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50236389(N-methyl-1-(6-methyl-4-(2-phenoxyphenoxy)pyridin-3...)
Affinity DataKi:  823nMAssay Description:Displacement of [3H]citalopram from human recombinant SERT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50236389(N-methyl-1-(6-methyl-4-(2-phenoxyphenoxy)pyridin-3...)
Affinity DataKi:  823nMAssay Description:Inhibition of [3H]Citalopram uptake in human 5HTT transfected HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50236389(N-methyl-1-(6-methyl-4-(2-phenoxyphenoxy)pyridin-3...)
Affinity DataKi:  1.91E+3nMAssay Description:Displacement of radioligand from human recombinant DAT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50236389(N-methyl-1-(6-methyl-4-(2-phenoxyphenoxy)pyridin-3...)
Affinity DataKi:  1.91E+3nMAssay Description:Inhibition of [3H]WIN-35428 uptake in human DAT transfected HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50236389(N-methyl-1-(6-methyl-4-(2-phenoxyphenoxy)pyridin-3...)
Affinity DataKi:  5.80E+3nMAssay Description:Displacement of [3H]dofetilide from human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed