BDBM50236334 CHEMBL4071240

SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NCCCCN2CCN(CC2)c2cccc(Cl)c2Cl)c1

InChI Key InChIKey=LHQYJFMEVSYGBX-UHFFFAOYSA-N

Data  3 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50236334   

TargetD(2) dopamine receptor(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50236334(CHEMBL4071240)
Affinity DataEC50:  45nMAssay Description:Agonist activity at human dopamine D2 receptor-short expressed in CHO-K1 cells assessed as reduction in adenylyl cyclase activator NKH 477 induced cA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2019
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50236334(CHEMBL4071240)
Affinity DataEC50:  0.900nMAssay Description:Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2019
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50236334(CHEMBL4071240)
Affinity DataEC50:  6.5nMAssay Description:Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2019
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50236334(CHEMBL4071240)
Affinity DataEC50:  0.900nMAssay Description:Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2019
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50236334(CHEMBL4071240)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human FAAH1 expressed in HEK293 cell membrane-enriched lysate using AMC arachidonyl amide as substrate preincubated for 50 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2019
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50236334(CHEMBL4071240)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human FAAH expressed in HEK293 cells using AMC arachidonyl amide as substrate pre-incubated for 50 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Assam University (A Central University)

Curated by ChEMBL
LigandPNGBDBM50236334(CHEMBL4071240)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of FAAH in Sprague-Dawley rat brain homogenate using arachidonoyl-ethanolamide and anandamide [ethanolamine-1-3H] as substrate pre-incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed