BDBM50235200 CHEMBL4098260

SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCN(C2)c2ccc(cn2)S(C)(=O)=O)CC1

InChI Key InChIKey=MNRNPWKNUOBWBG-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50235200   

LigandPNGBDBM50235200(CHEMBL4098260)
Affinity DataIC50: 29nMAssay Description:Inhibition of human ROMK expressed in CHO cells by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2019
Entry Details Article
PubMed
LigandPNGBDBM50235200(CHEMBL4098260)
Affinity DataIC50: 1.17E+4nMAssay Description:Inhibition of human ERG by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2019
Entry Details Article
PubMed
LigandPNGBDBM50235200(CHEMBL4098260)
Affinity DataIC50: 41nMAssay Description:Inhibition of human ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2019
Entry Details Article
PubMed
LigandPNGBDBM50235200(CHEMBL4098260)
Affinity DataIC50: 1.44E+4nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2019
Entry Details Article
PubMed
LigandPNGBDBM50235200(CHEMBL4098260)
Affinity DataIC50: 60nMAssay Description:Inhibition of rat ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2019
Entry Details Article
PubMed
LigandPNGBDBM50235200(CHEMBL4098260)
Affinity DataIC50: 41.1nMAssay Description:Assay Protocol: The ROMK channel functional thallium flux assay was performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
Go to US Patent

LigandPNGBDBM50235200(CHEMBL4098260)
Affinity DataIC50: 1.44E+4nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2019
Entry Details Article
PubMed
LigandPNGBDBM50235200(CHEMBL4098260)
Affinity DataIC50: 1.17E+4nMAssay Description:Inhibition of human ERG by Qpatch electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2019
Entry Details Article
PubMed
LigandPNGBDBM50235200(CHEMBL4098260)
Affinity DataIC50: 29nMAssay Description:Inhibition of human ROMK expressed in CHO cells at -70 mV holding potential after 6 mins by whole cell patch clamp Qpatch methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2019
Entry Details Article
PubMed
LigandPNGBDBM50235200(CHEMBL4098260)
Affinity DataIC50: 41nMAssay Description:Inhibition of human ROMK channel expressed in HEK293 cells after 30 mins by FLIPR based thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2019
Entry Details Article
PubMed