BDBM50235020 CHEMBL4094492

SMILES CC(C)n1cnc2c(Nc3cc(Cl)cc(NC(C)=O)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12

InChI Key InChIKey=ZYFRJAWGLQYBTJ-UHFFFAOYSA-N

Data  14 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50235020   

TargetDual specificity protein kinase CLK1(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50235020(CHEMBL4094492)
Affinity DataIC50: 19nMAssay Description:Inhibition of human CLK1 using substrate ERMRPRKRQGSVRRRV in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2019
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK1(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50235020(CHEMBL4094492)
Affinity DataIC50: 19nMAssay Description:Inhibition of human CLK1 using substrate ERMRPRKRQGSVRRRV in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2019
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50235020(CHEMBL4094492)
Affinity DataIC50: 7nMAssay Description:Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2019
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK4(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50235020(CHEMBL4094492)
Affinity DataIC50: 64nMAssay Description:Inhibition of human CLK4 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2019
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK4(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50235020(CHEMBL4094492)
Affinity DataIC50: 64nMAssay Description:Inhibition of human CLK4 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2019
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50235020(CHEMBL4094492)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CDK1/cyclinB using Histone H1 as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2019
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50235020(CHEMBL4094492)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CDK1/cyclinB using Histone H1 as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2019
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK1(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50235020(CHEMBL4094492)
Affinity DataEC50:  7.30E+3nMAssay Description:Inhibition of CLK mediated SF3B1 activation in human SK-MEL-2 cells assessed as MDM2-pre mRNA exon skipping after 4 hrs by luciferase reporter gene a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2019
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK1(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50235020(CHEMBL4094492)
Affinity DataEC50:  7.30E+3nMAssay Description:Inhibition of CLK mediated SF3B1 activation in human SK-MEL-2 cells assessed as MDM2-pre mRNA exon skipping after 4 hrs by luciferase reporter gene a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2019
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK3(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50235020(CHEMBL4094492)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CLK3 using ERMRPRKRQGSVRRRV as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2019
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK3(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50235020(CHEMBL4094492)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CLK3 using ERMRPRKRQGSVRRRV as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2019
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50235020(CHEMBL4094492)
Affinity DataIC50: 7nMAssay Description:Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2019
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50235020(CHEMBL4094492)
Affinity DataIC50: 930nMAssay Description:Inhibition of human CDK4/cyclinD3 using Histone H1 as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2019
Entry Details Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50235020(CHEMBL4094492)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CDK6/cyclinD3 using Histone H1 as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2019
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50235020(CHEMBL4094492)
Affinity DataIC50: 930nMAssay Description:Inhibition of human CDK4/cyclinD3 using Histone H1 as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2019
Entry Details Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50235020(CHEMBL4094492)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CDK6/cyclinD3 using Histone H1 as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2019
Entry Details Article
PubMed