BDBM50234509 4-(2-(5-chloro-1-methyl-1H-imidazol-4-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one::CHEMBL256072

SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCc2ncn(C)c2Cl)cc[nH]c1=O)N1CCOCC1

InChI Key InChIKey=GLISBSFAODYFPL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50234509   

TargetInsulin-like growth factor 1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50234509(4-(2-(5-chloro-1-methyl-1H-imidazol-4-yl)ethylamin...)
Affinity DataIC50: 38nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50234509(4-(2-(5-chloro-1-methyl-1H-imidazol-4-yl)ethylamin...)
Affinity DataIC50: 336nMAssay Description:Inhibition of IGF1R expressed in SAL cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50234509(4-(2-(5-chloro-1-methyl-1H-imidazol-4-yl)ethylamin...)
Affinity DataIC50: 38nMAssay Description:Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50234509(4-(2-(5-chloro-1-methyl-1H-imidazol-4-yl)ethylamin...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP3A4 after 20 mins by BFC fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed