BDBM50233877 CHEMBL4068176

SMILES Fc1cccc(c1)-c1csc2nc([nH]c(=O)c12)C(=O)NCc1cccc(OCCOc2nc[nH]n2)c1

InChI Key InChIKey=MLUCCAMJMIYYED-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50233877   

TargetMatrilysin(Human)
Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50233877(CHEMBL4068176)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of APMA-activated recombinant human MMP-7 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2019
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50233877(CHEMBL4068176)
Affinity DataIC50: 180nMAssay Description:Inhibition of APMA-activated recombinant human MMP-2 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2019
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50233877(CHEMBL4068176)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of APMA-activated recombinant human MMP-8 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2019
Entry Details Article
PubMed
TargetStromelysin-2(Human)
Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50233877(CHEMBL4068176)
Affinity DataIC50: 55nMAssay Description:Inhibition of APMA-activated recombinant human MMP-10 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2019
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50233877(CHEMBL4068176)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of APMA-activated recombinant human MMP-1 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2019
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50233877(CHEMBL4068176)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of APMA-activated recombinant human MMP-3 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2019
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50233877(CHEMBL4068176)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of APMA-activated recombinant human GST-tagged MMP-14 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2019
Entry Details Article
PubMed
LigandPNGBDBM50233877(CHEMBL4068176)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TACE (unknown origin) using Cy3-PLAQAV(Cy5Q-L-2,3-diaminopropionic acid)-RSSSR-NH2 peptide as substrate measured after 40 mins by spect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2019
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50233877(CHEMBL4068176)
Affinity DataIC50: 0.0360nMAssay Description:Inhibition of APMA-activated recombinant human MMP-13 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2019
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50233877(CHEMBL4068176)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of APMA-activated recombinant human MMP-9 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2019
Entry Details Article
PubMed