BDBM50233516 CHEMBL4097990

SMILES COc1cc(ccc1F)C1(C)CCCc2nc(SCc3c(F)cc(OCCOCCOCCN(C)C)cc3F)n(c12)-c1ccc(F)cc1

InChI Key InChIKey=PQMGYLOMTOOZCE-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50233516   

TargetG-protein coupled bile acid receptor 1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50233516(CHEMBL4097990)
Affinity DataEC50:  2.51E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2019
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50233516(CHEMBL4097990)
Affinity DataEC50:  1.09E+3nMAssay Description:Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2019
Entry Details Article
PubMed