BDBM50233476 CHEMBL4087370

SMILES COc1cc(ccc1Cl)C1CCCc2nc(SCc3c(F)cccc3[N+]([O-])=O)n(c12)-c1ccc(F)cc1

InChI Key InChIKey=KPSJFBOIUGFALY-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50233476   

TargetG-protein coupled bile acid receptor 1(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50233476(CHEMBL4087370)
Affinity DataEC50:  397nMAssay Description:Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2019
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50233476(CHEMBL4087370)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2019
Entry Details Article
PubMed