BDBM50233341 2-(3-isopropylureido)-N-(2-((1S,2R)-2-(4-(methylthio)benzamido)cyclohexylamino)-2-oxoethyl)-5-(trifluoromethyl)benzamide::CHEMBL273083

SMILES CSc1ccc(cc1)C(=O)N[C@@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1cc(ccc1NC(=O)NC(C)C)C(F)(F)F

InChI Key InChIKey=IBPXYDUJQWENPM-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50233341   

TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50233341(2-(3-isopropylureido)-N-(2-((1S,2R)-2-(4-(methylth...)
Affinity DataIC50: 5.10nMAssay Description:Displacement of [125I]MCP1 from CCR2 in human PBMC by millipore filter plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50233341(2-(3-isopropylureido)-N-(2-((1S,2R)-2-(4-(methylth...)
Affinity DataIC50: 18nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced calcium flux by fluorescence-imaging plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50233341(2-(3-isopropylureido)-N-(2-((1S,2R)-2-(4-(methylth...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50233341(2-(3-isopropylureido)-N-(2-((1S,2R)-2-(4-(methylth...)
Affinity DataIC50: 5.10E+3nMAssay Description:Displacement of [125I]MCP1 from human CCR2B receptor expressed in HEK293-EBNA cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50233341(2-(3-isopropylureido)-N-(2-((1S,2R)-2-(4-(methylth...)
Affinity DataIC50: 5.10nMAssay Description:Displacement of radiolabeled MCP1 from human CCR2 in PBMCsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50233341(2-(3-isopropylureido)-N-(2-((1S,2R)-2-(4-(methylth...)
Affinity DataIC50: 18nMAssay Description:Antagonist activity at human CCR2 in PBMCs assessed as inhibition of MCP1-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50233341(2-(3-isopropylureido)-N-(2-((1S,2R)-2-(4-(methylth...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human CCR2 in PBMCs assessed as inhibition of chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50233341(2-(3-isopropylureido)-N-(2-((1S,2R)-2-(4-(methylth...)
Affinity DataIC50: 7.5nMAssay Description:Binding affinity to wild type CCR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed