BDBM50233281 CHEMBL4084995

SMILES OC(=O)c1ccccc1CC[C@@H]1CCC[C@@H]1NC(=O)C1CCN(CC1)c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=KBUZYHIZZSDSNF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50233281   

TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233281(CHEMBL4084995)
Affinity DataIC50: 1nMAssay Description:Inhibition of human mPGES1 expressed in HEK293 microsomes assessed as reduction in PGE2 production using PGH2 as substrate after 2.5 mins by LC-MS an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233281(CHEMBL4084995)
Affinity DataIC50: 10nMAssay Description:Inhibition of mPGES1 in human whole blood assessed as reduction in LPS-induced PGE2 production preincubated for 30 mins followed by LPS addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed