BDBM50233202 CHEMBL4092208

SMILES Cc1ccccc1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(\C=C\C(O)=O)cc1

InChI Key InChIKey=FXDNMIHYFCBOCB-UHFFFAOYSA-N

Data  1 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50233202   

TargetEstrogen receptor(Human)
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50233202(CHEMBL4092208)
Affinity DataEC50:  1.10nMAssay Description:Induction of ERalpha degradation in tamoxifen-sensitive human MCF7:WS8 cells after 24 hrs by CellTag 700 staining based In-cell western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50233202(CHEMBL4092208)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at ERalpha in tamoxifen-sensitive human MCF7:WS8 cells assessed as inhibition of estradiol-induced response after 18 hrs by lucif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50233202(CHEMBL4092208)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]estradiol from full length recombinant human ESR1 expressed in insect cells by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details Article
PubMed