BDBM50232824 CHEMBL4060996

SMILES COc1ccc(cc1)N(C)c1nc(C)nc2c(Cc3ccccc3)cn(C)c12

InChI Key InChIKey=GCKTWBJEXJWFHY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50232824   

TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50232824(CHEMBL4060996)
Affinity DataIC50: 33nMAssay Description:Inhibition of VEGFR-2 in human U251 cells assessed as reduction in VEGF induced phosphorylation preincubated for 60 mins followed by VEGF addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2019
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50232824(CHEMBL4060996)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF induced phosphorylation preincubated for 60 mins followed by EGF addition measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2019
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50232824(CHEMBL4060996)
Affinity DataIC50: 10nMAssay Description:Inhibition of PDGFR-beta in human SF539 cells assessed as reduction in PDGF-BB induced phosphorylation preincubated for 60 mins followed by PDGF-BB a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2019
Entry Details Article
PubMed