BDBM50232452 CHEMBL4070023::US10214537, Example 229

SMILES COc1cc(cc(c1)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12)N1[C@@H](C)CN(C[C@H]1C)C(C)=O

InChI Key InChIKey=PIVJFAZFMAGLNZ-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50232452   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Bristol-Myers Squibb

Curated by ChEMBL

LigandBDBM50232452(CHEMBL4070023 | US10214537, Example 229)Copy SMILESCopy InChI

Affinity DataIC50: 1.20nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate incubated for 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
5/14/2019
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Bristol-Myers Squibb

Curated by ChEMBL

LigandBDBM50232452(CHEMBL4070023 | US10214537, Example 229)Copy SMILESCopy InChI

Affinity DataIC50: 1nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/20/2019
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL