BDBM50232441 CHEMBL4101075::US10214537, Example 535

SMILES CC(=O)N1CCN(CC1)c1cccc(c1)-c1cc(-c2ccnn2CC(F)(F)F)c2c(N)ncnn12

InChI Key InChIKey=NHTBEIFBWSUCGT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50232441   

LigandPNGBDBM50232441(CHEMBL4101075 | US10214537, Example 535)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate incubated for 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2019
Entry Details Article
PubMed
LigandPNGBDBM50232441(CHEMBL4101075 | US10214537, Example 535)
Affinity DataIC50: 143nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as suppression of CD69 expression incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2019
Entry Details Article
PubMed
LigandPNGBDBM50232441(CHEMBL4101075 | US10214537, Example 535)
Affinity DataIC50: 6nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent