BDBM50232241 4-(2-Chlorophenyl)-9-hydroxy-6-(3-hydroxypropyl)-pyrrolo[3,4-c]carbazole-1,3(2H,6H )-dione::4-(2-chlorophenyl)-9-hydroxy-6-(3-hydroxypropyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione::CHEMBL411662

SMILES OCCCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1ccccc1Cl

InChI Key InChIKey=MXQJCXBZZGUBSZ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50232241   

TargetSerine/threonine-protein kinase Chk1(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50232241(4-(2-Chlorophenyl)-9-hydroxy-6-(3-hydroxypropyl)-p...)
Affinity DataIC50: 170nMAssay Description:Inhibition of Chk1 kinase assessed as GST-Cdc25 phosphorylation by Western blot determinationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50232241(4-(2-Chlorophenyl)-9-hydroxy-6-(3-hydroxypropyl)-p...)
Affinity DataIC50: 650nMAssay Description:Inhibition of Cdc2/cyclin B assessed as inhibition of histone H1 phosphorylation in human HT29 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50232241(4-(2-Chlorophenyl)-9-hydroxy-6-(3-hydroxypropyl)-p...)
Affinity DataIC50: 170nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50232241(4-(2-Chlorophenyl)-9-hydroxy-6-(3-hydroxypropyl)-p...)
Affinity DataIC50: 250nMAssay Description:Inhibition of human Cdc2 kinase PY15 phosphorylation in HT29 cells by Western blotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetWee1-like protein kinase(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50232241(4-(2-Chlorophenyl)-9-hydroxy-6-(3-hydroxypropyl)-p...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50232241(4-(2-Chlorophenyl)-9-hydroxy-6-(3-hydroxypropyl)-p...)
Affinity DataIC50: 250nMAssay Description:Inhibition of Cdc2 Tyr15 phosphorylation in human HT29 cells by western blotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetWee1-like protein kinase(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50232241(4-(2-Chlorophenyl)-9-hydroxy-6-(3-hydroxypropyl)-p...)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of human Wee1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetWee1-like protein kinase(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50232241(4-(2-Chlorophenyl)-9-hydroxy-6-(3-hydroxypropyl)-p...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human Wee1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed