BDBM50232166 CHEMBL4071588

SMILES Oc1ccc(cc1)-c1ccc(s1)C(=O)c1c(F)ccc(O)c1F

InChI Key InChIKey=HDNHNXBACWULOX-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50232166   

Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50232166(CHEMBL4071588)
Affinity DataIC50: 3nMAssay Description:Inhibition of human placental cytosolic 17beta-HSD1 assessed as reduction in activation of [2,4,6,7-3H]-E1 substrate to E2 after 10 mins in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2019
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50232166(CHEMBL4071588)
Affinity DataIC50: 71nMAssay Description:Inhibition of human placental microsomal 17beta-HSD2 using [2,4,6,7-3H]-E2 as substrate after 20 mins in presence of NAD+ by RP-HPLC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2019
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50232166(CHEMBL4071588)
Affinity DataIC50: 71nMAssay Description:Inhibition of human placental cytosolic 17beta-HSD2 using [3H]-E2/E2 substrate and NAD+ after 20 mins by HPLC based radio-detection methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50232166(CHEMBL4071588)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of 17beta-HSD1 in human T47D cells preincubated for 1 hr followed by addition of [3H]-E1/E1 as substrate measured after 30 mins by HPLC ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50232166(CHEMBL4071588)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human placental cytosolic 17beta-HSD1 using [3H]-E1/E1 substrate and NADH after 10 mins by HPLC based radio-detection methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50232166(CHEMBL4071588)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of human 17beta-HSD1 expressed in human T47D cells using [3H]E1 as substrate incubated for 1 hr followed by substrate addition measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed