BDBM50231822 CHEMBL4067221::US11725000, Compound 99

SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(=O)[nH]c1

InChI Key InChIKey=KVRHVNXXSLPRDR-UHFFFAOYSA-N

Data  2 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50231822   

TargetSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial(Human)
Peking University

Curated by ChEMBL

LigandBDBM50231822(CHEMBL4067221 | US11725000, Compound 99)Copy SMILESCopy InChI

Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
5/7/2019
Entry Details Article
Copy Entry DOIPubMed
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TargetSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial(Human)
Peking University

Curated by ChEMBL

LigandBDBM50231822(CHEMBL4067221 | US11725000, Compound 99)Copy SMILESCopy InChI

Affinity DataEC50: <1.00E+5nMAssay Description:In order to identify the target protein of tTC09 apoptosis inhibitors, we synthesized two sets of probes for target identification based on the SAR s...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/21/2023
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL