BDBM50231783 CHEMBL4078220::US11725000, Compound 155

SMILES COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(=O)(=O)CCCC(=O)N2CCCCC2)C(F)(F)F)cc1OC

InChI Key InChIKey=JDXPTRAYQSWQFM-UHFFFAOYSA-N

Data  2 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50231783   

TargetSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial(Human)
Peking University

Curated by ChEMBL

LigandBDBM50231783(CHEMBL4078220 | US11725000, Compound 155)Copy SMILESCopy InChI

Affinity DataEC50:  1.40nMAssay Description:Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
5/7/2019
Entry Details Article
Copy Entry DOIPubMed
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TargetSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial(Human)
Peking University

Curated by ChEMBL

LigandBDBM50231783(CHEMBL4078220 | US11725000, Compound 155)Copy SMILESCopy InChI

Affinity DataEC50:  5.01E+5nMAssay Description:In order to identify the target protein of tTC09 apoptosis inhibitors, we synthesized two sets of probes for target identification based on the SAR s...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/21/2023
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL