BDBM50231741 2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one::CHEMBL252956

SMILES O=C1CCCc2nc(ccc12)C#Cc1ccccc1

InChI Key InChIKey=XOUDFZJCSDKXLG-UHFFFAOYSA-N

Data  1 KI  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50231741   

TargetMetabotropic glutamate receptor 5(Human)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50231741(2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one | CH...)
Affinity DataEC50:  50nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50231741(2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one | CH...)
Affinity DataEC50:  14nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in human HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliza...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50231741(2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one | CH...)
Affinity DataEC50:  172nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as L-glutamate induced potentiation of intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231741(2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one | CH...)
Affinity DataEC50:  34nMAssay Description:Antagonist activity at mGluR5 in Sprague-Dawley rat astrocyte assessed as L-quisqualate induced potentiation of intracellular calcium level by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231741(2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one | CH...)
Affinity DataKi:  800nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed