BDBM50231682 CHEMBL251862::N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide

SMILES CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@@H](C)C(=O)NC1CCCCC1)N1CCCC1=O

InChI Key InChIKey=ARWMRRUIIHCDKG-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50231682   

TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231682(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 310nMAssay Description:Inhibition of BACE1 assessed as beta amyloid 40 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231682(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 360nMAssay Description:Inhibition of BACE1 assessed as beta amyloid 42 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231682(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 13nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231682(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 310nMAssay Description:Inhibition of BACE1 expressed in SHSY5Y cells assessed as reduction of amyloid beta 40 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231682(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 13nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231682(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 360nMAssay Description:Inhibition of BACE1 expressed in SHSY5Y cells assessed as reduction of amyloid beta 42 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231682(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 13nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231682(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 307nMAssay Description:Inhibition of BACE1 assessed as inhibition of amyloid beta-40 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231682(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 363nMAssay Description:Inhibition of BACE1 assessed as inhibition of amyloid beta-42 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231682(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 1.81E+3nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231682(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231682(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 1.81E+3nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231682(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231682(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 1.81E+3nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231682(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed