BDBM50230972 CHEMBL4069394

SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)-n3cccc3CN(C)C)c3ccccc3)C(=O)Nc2c1

InChI Key InChIKey=WNMAXXDDBQOLPI-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50230972   

TargetVascular endothelial growth factor receptor 2(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL
LigandPNGBDBM50230972(CHEMBL4069394)
Affinity DataIC50: 52nMAssay Description:Inhibition of human N-terminal GST-tagged VEGFR2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2019
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL
LigandPNGBDBM50230972(CHEMBL4069394)
Affinity DataIC50: 9.60nMAssay Description:Inhibition of recombinant human GST-tagged VEGFR3 cytoplasmic domain expressed in baculovirus expression system preincubated for 10 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2019
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL
LigandPNGBDBM50230972(CHEMBL4069394)
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant human GST-tagged FGFR1 cytoplasmic domain (398 to 822 residues) expressed in baculovirus expression system preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2019
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL
LigandPNGBDBM50230972(CHEMBL4069394)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of PDGFRalpha (unknown origin) preincubated for 10 mins followed by FAM-labeled peptide substrate addition measured after 1 hr by mobility...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2019
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL
LigandPNGBDBM50230972(CHEMBL4069394)
Affinity DataIC50: 99nMAssay Description:Inhibition of recombinant human GST-tagged VEGFR1 cytoplasmic domain (781 to 1338 residues) expressed in baculovirus expression system preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2019
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL
LigandPNGBDBM50230972(CHEMBL4069394)
Affinity DataIC50: 14nMAssay Description:Inhibition of human N-terminal GST-tagged PDGFRbeta cytoplasmic domain (557 to 1106 residues) expressed in baculovirus expression system preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2019
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL
LigandPNGBDBM50230972(CHEMBL4069394)
Affinity DataIC50: 82nMAssay Description:Inhibition of N-terminal GST fused human VEGFR2 cytoplasmic domain (790 to 1356 (end) residues) expressed in baculovirus expression system using FAM-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL
LigandPNGBDBM50230972(CHEMBL4069394)
Affinity DataIC50: 11nMAssay Description:Inhibition of N-terminal GST-fused human PDGFRbeta cytoplasmic domain (557 to 1106 (end) residues) expressed in baculovirus expression system using F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed