BDBM50230168 CHEMBL4079662::US10377763, Example 4

SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC[C@@]14[C@@]5(O)CC[C@H]2N(C)C(=O)\C=C\c1ccoc1)S(=O)(=O)c1ccc(C)cc1)ccc3OC

InChI Key

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50230168   

TargetOrexin/Hypocretin receptor type 1(Human)
University of Tsukuba

US Patent
LigandPNGBDBM50230168(CHEMBL4079662 | US10377763, Example 4)
Affinity DataIC50: 162nMAssay Description:The Chinese hamster ovary (CHO) cell lines CHOOX1R and CHOOX2R were established by modifying CHO cells to constantly express the NFAT-luciferase gene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
University of Tsukuba

US Patent
LigandPNGBDBM50230168(CHEMBL4079662 | US10377763, Example 4)
Affinity DataIC50: 1.00E+4nMAssay Description:The Chinese hamster ovary (CHO) cell lines CHOOX1R and CHOOX2R were established by modifying CHO cells to constantly express the NFAT-luciferase gene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
University of Tsukuba

US Patent
LigandPNGBDBM50230168(CHEMBL4079662 | US10377763, Example 4)
Affinity DataKi:  5.90nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2019
Entry Details Article
PubMed