BDBM50229190 CHEMBL253869::N-(4-amino-biphenyl-3-yl)-4-[(3-pyridin-3-yl-propionylamino)-methyl]-benzamide::US9096559, 14a::US9096559, 53

SMILES Nc1ccc(cc1NC(=O)c1ccc(CNC(=O)CCc2cccnc2)cc1)-c1ccccc1

InChI Key InChIKey=KZSQGUCOPQRCMU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50229190   

TargetHistone deacetylase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50229190(N-(4-amino-biphenyl-3-yl)-4-[(3-pyridin-3-yl-propi...)
Affinity DataIC50: 16nMAssay Description:Novel compounds were tested for their ability to inhibit histone deacetylase, subtype 1 (HDAC1) using an in vitro deacetylation assay. The enzyme sou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50229190(N-(4-amino-biphenyl-3-yl)-4-[(3-pyridin-3-yl-propi...)
Affinity DataIC50: 11nMAssay Description:Novel compounds were tested for their ability to inhibit histone deacetylase, subtype 1 (HDAC1) using an in vitro deacetylation assay. The enzyme sou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50229190(N-(4-amino-biphenyl-3-yl)-4-[(3-pyridin-3-yl-propi...)
Affinity DataIC50: 11nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50229190(N-(4-amino-biphenyl-3-yl)-4-[(3-pyridin-3-yl-propi...)
Affinity DataIC50: 3.70E+3nMAssay Description:Displacement of [35S]MK-499 from ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed