BDBM50229189 CHEMBL253868::US9096559, 2a::[4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbamic acid pyridin-3-ylmethyl ester

SMILES Nc1ccc(cc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1)-c1ccccc1

InChI Key InChIKey=AXVLWKBVIHOIQB-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50229189   

TargetHistone deacetylase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50229189([4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbam...)
Affinity DataIC50: 10nMAssay Description:Novel compounds were tested for their ability to inhibit histone deacetylase, subtype 1 (HDAC1) using an in vitro deacetylation assay. The enzyme sou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50229189([4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbam...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of HDAC5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50229189([4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbam...)
Affinity DataIC50: 3.00E+3nMAssay Description:Displacement of [35S]MK-499 from ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50229189([4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbam...)
Affinity DataIC50: 72nMAssay Description:Inhibition of HDAC2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50229189([4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbam...)
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50229189([4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbam...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HDAC8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50229189([4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbam...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of HDAC6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50229189([4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbam...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of HDAC7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50229189([4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbam...)
Affinity DataIC50: 6.18E+3nMAssay Description:Inhibition of HDAC3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50229189([4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbam...)
Affinity DataIC50: 15nMAssay Description:Inhibition of C-terminal flag-tagged recombinant human HDAC1 expressed in HEK293F cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50229189([4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbam...)
Affinity DataIC50: 5nMAssay Description:Inhibition of C-terminal flag-tagged recombinant human HDAC1 expressed in HEK293F cells measured after 1 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50229189([4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbam...)
Affinity DataIC50: 2nMAssay Description:Inhibition of C-terminal flag-tagged recombinant human HDAC1 expressed in HEK293F cells measured after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed