BDBM50229025 CHEMBL4092421

SMILES CCC(C)(C)C(=O)N(O)Cc1ccccc1

InChI Key InChIKey=AVYVHIKSFXVDBG-UHFFFAOYSA-N

Data  7 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50229025   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50229025(CHEMBL4092421)
Affinity DataEC50:  28nMAssay Description:Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2019
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Mouse)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50229025(CHEMBL4092421)
Affinity DataEC50:  27nMAssay Description:Inhibition of RIP1 in mouse L929 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 6 hrs by Cell Titer-Glo luminescent cell vi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2019
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50229025(CHEMBL4092421)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50229025(CHEMBL4092421)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50229025(CHEMBL4092421)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2019
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50229025(CHEMBL4092421)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2019
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50229025(CHEMBL4092421)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2019
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50229025(CHEMBL4092421)
Affinity DataIC50: 13nMAssay Description:Inhibition of RIP1 (unknown origin) using MBP as substrate preincubated for 15 mins followed by MBP/ATP mixture addition measured after 90 mins by AD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2019
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50229025(CHEMBL4092421)
Affinity DataIC50: 298nMAssay Description:Inhibition of human RIPK1 incubated for 40 min in presence of ATP by ADP-Glo luminescence kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed