BDBM50228005 (6S,7S)-6-(4-m-tolyl-piperazine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide::CHEMBL404132

SMILES Cc1cccc(c1)N1CCN(CC1)C(=O)[C@H]1NCC2(CC2)C[C@@H]1C(=O)NO

InChI Key InChIKey=KAJHXHOIEARPHN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50228005   

TargetMatrix metalloproteinase-9(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50228005((6S,7S)-6-(4-m-tolyl-piperazine-1-carbonyl)-5-aza-...)
Affinity DataIC50: 1.27E+3nMAssay Description:Binding affinity to MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50228005((6S,7S)-6-(4-m-tolyl-piperazine-1-carbonyl)-5-aza-...)
Affinity DataIC50: 184nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50228005((6S,7S)-6-(4-m-tolyl-piperazine-1-carbonyl)-5-aza-...)
Affinity DataIC50: 63nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50228005((6S,7S)-6-(4-m-tolyl-piperazine-1-carbonyl)-5-aza-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity to MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50228005((6S,7S)-6-(4-m-tolyl-piperazine-1-carbonyl)-5-aza-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Binding affinity to MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50228005((6S,7S)-6-(4-m-tolyl-piperazine-1-carbonyl)-5-aza-...)
Affinity DataIC50: 187nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed