BDBM50227990 (6S,7S)-6-[4-(4-cyano-3,5-dimethyl-phenyl)-3,6-dihydro-2H-pyridine-1-carbonyl]-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide::CHEMBL403380

SMILES Cc1cc(cc(C)c1C#N)C1=CCN(CC1)C(=O)[C@H]1NCC2(CC2)C[C@@H]1C(=O)NO

InChI Key InChIKey=JLFCWOIZNQXZMP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50227990   

LigandPNGBDBM50227990((6S,7S)-6-[4-(4-cyano-3,5-dimethyl-phenyl)-3,6-dih...)
Affinity DataIC50: 28nMAssay Description:Binding affinity to ADAM10More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50227990((6S,7S)-6-[4-(4-cyano-3,5-dimethyl-phenyl)-3,6-dih...)
Affinity DataIC50: 5.00E+3nMAssay Description:Binding affinity to MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50227990((6S,7S)-6-[4-(4-cyano-3,5-dimethyl-phenyl)-3,6-dih...)
Affinity DataIC50: 159nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50227990((6S,7S)-6-[4-(4-cyano-3,5-dimethyl-phenyl)-3,6-dih...)
Affinity DataIC50: 3.50E+3nMAssay Description:Binding affinity to MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50227990((6S,7S)-6-[4-(4-cyano-3,5-dimethyl-phenyl)-3,6-dih...)
Affinity DataIC50: 5.00E+3nMAssay Description:Binding affinity to MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50227990((6S,7S)-6-[4-(4-cyano-3,5-dimethyl-phenyl)-3,6-dih...)
Affinity DataIC50: 129nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed