BDBM50227083 CHEMBL173443

SMILES CCCCCc1ccc(cc1)/C=C/C(=O)Nc2ccccc2C(=O)O

InChI Key InChIKey=GAMRBCZMOOMBSQ-UHFFFAOYSA-N

Data  9 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50227083   

TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of LTC4 induced smooth muscle contraction of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2018
Entry Details Article
PubMed
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced channel currents by whole cell patch clamp electrophysiolog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataIC50: 320nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced channel currents treated extracellularly after 60 secs by w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in H2O2-induced intracellular calcium flux after 30 mins by Fluo4-AM dye ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in H2O2-induced intracellular calcium flux after 30 mins by Fluo4-AM dye ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced intracellular calcium flux at 0 mV holding potential by who...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2020
Entry Details Article
PubMed
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataEC50:  2.82E+4nMAssay Description:Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataEC50:  2.80E+4nMAssay Description:Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of human TRPM8 expressed in HEK293T cells assessed as blocked of menthol-activated current by whole cell patch clamp electrophysiology rel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetPhospholipase A2(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of PLA2 (unknown origin) using soybean phosphatidylcholine as substrate preincubated for 30 mins followed incubated for 60 mins after subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed