BDBM50225164 1-({4-[(5-fluoro-2-methylbenzene)amido]-2-methoxyphenyl}carbonyl)-1,2,3,5-tetrahydrospiro[1-benzazepine-4,1'-cyclopentan]-2'-ene-3'-carboxylic acid::CHEMBL249133

SMILES COc1cc(NC(=O)c2cc(F)ccc2C)ccc1C(=O)N1CCC2(CCC(=C2)C(O)=O)Cc2ccccc12

InChI Key InChIKey=ZQWDFLJKWPBHNX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50225164   

TargetVasopressin V2 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225164(1-({4-[(5-fluoro-2-methylbenzene)amido]-2-methoxyp...)
Affinity DataIC50: 110nMAssay Description:Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225164(1-({4-[(5-fluoro-2-methylbenzene)amido]-2-methoxyp...)
Affinity DataIC50: 1.16E+4nMAssay Description:Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetVasopressin V2 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225164(1-({4-[(5-fluoro-2-methylbenzene)amido]-2-methoxyp...)
Affinity DataIC50: 140nMAssay Description:Antagonist activity at human vasopressin V2 receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed