BDBM50224871 (6S,11R)-3-cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocine-8-carboxylic acid (3-naphthalen-2-yl-propyl)-amide::CHEMBL430397

SMILES C[C@H]1C2Cc3ccc(cc3[C@@]1(C)CCN2CC1CC1)C(=O)NCCCc1ccc2ccccc2c1

InChI Key InChIKey=LOUFHRFNYKWWBM-UHFFFAOYSA-N

Data  3 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50224871   

TargetMu-type opioid receptor(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM50224871((6S,11R)-3-cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataIC50: 320nMAssay Description:Antagonist activity at human mu opioid receptor expressed in CHO cell membrane assessed as inhibition of DAMGO induced [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM50224871((6S,11R)-3-cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cell membrane by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM50224871((6S,11R)-3-cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataEC50:  6.30nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM50224871((6S,11R)-3-cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM50224871((6S,11R)-3-cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM50224871((6S,11R)-3-cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]naltrindole from delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed