BDBM50224775 (2R,3R,4R,5R)-2-(6-(cyclopentylamino)-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-3,4-diol::CHEMBL400189

SMILES C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(NC3CCCC3)ncnc12

InChI Key InChIKey=BVOLJUDYJILMMW-UHFFFAOYSA-N

Data  12 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50224775   

TargetAdenosine receptor A1(Bovine)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50224775((2R,3R,4R,5R)-2-(6-(cyclopentylamino)-9H-purin-9-y...)
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]CCPA from adenosine A1 receptor in bovine cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50224775((2R,3R,4R,5R)-2-(6-(cyclopentylamino)-9H-purin-9-y...)
Affinity DataKi:  4.52nMAssay Description:Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Bovine)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50224775((2R,3R,4R,5R)-2-(6-(cyclopentylamino)-9H-purin-9-y...)
Affinity DataKi:  9.5nMAssay Description:Inhibitory activity at Adenosine A1 receptor by inhibition of [3H]CHA binding to bovine brain cortical membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Guinea pig)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50224775((2R,3R,4R,5R)-2-(6-(cyclopentylamino)-9H-purin-9-y...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]CCPA from adenosine A1 receptor in pig cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Bovine)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50224775((2R,3R,4R,5R)-2-(6-(cyclopentylamino)-9H-purin-9-y...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]DPCPX binding to adenosine A1 receptors of bovine cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetAdenosine receptor A3(Rat)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50224775((2R,3R,4R,5R)-2-(6-(cyclopentylamino)-9H-purin-9-y...)
Affinity DataKi:  208nMAssay Description:Inhibitory activity against Adenosine A3 receptor by inhibiting specific [3H](R)-PIA binding to rat testis membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50224775((2R,3R,4R,5R)-2-(6-(cyclopentylamino)-9H-purin-9-y...)
Affinity DataKi:  879nMAssay Description:Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50224775((2R,3R,4R,5R)-2-(6-(cyclopentylamino)-9H-purin-9-y...)
Affinity DataKi:  7.22E+3nMAssay Description:Inhibitory activity at Adenosine A2A receptor by inhibition of [3H]-CGS- 21680 binding to bovine striatal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Bovine)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50224775((2R,3R,4R,5R)-2-(6-(cyclopentylamino)-9H-purin-9-y...)
Affinity DataKi:  7.23E+3nMAssay Description:Displacement of [3H]CGS21680 from adenosine A1 receptor in bovine striatum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50224775((2R,3R,4R,5R)-2-(6-(cyclopentylamino)-9H-purin-9-y...)
Affinity DataKi:  1.04E+4nMAssay Description:Displacement of [3H]NECA from human recombinant adenosine A2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Guinea pig)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50224775((2R,3R,4R,5R)-2-(6-(cyclopentylamino)-9H-purin-9-y...)
Affinity DataKi:  1.14E+4nMAssay Description:Displacement of [3H]CGS21680 from adenosine A1 receptor in pig striatum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50224775((2R,3R,4R,5R)-2-(6-(cyclopentylamino)-9H-purin-9-y...)
Affinity DataKi:  2.68E+4nMAssay Description:Displacement of [3H]NECA from human recombinant adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed