BDBM50224368 1-(2-chloro-2-phenylethyl)-N-(3-chlorophenyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine::CHEMBL400211

SMILES CSc1nc(Nc2cccc(Cl)c2)c2cnn(CC(Cl)c3ccccc3)c2n1

InChI Key InChIKey=ZSKSRKTYCCBGOO-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50224368   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50224368(1-(2-chloro-2-phenylethyl)-N-(3-chlorophenyl)-6-(m...)
Affinity DataKi:  600nMAssay Description:Inhibition of human recombinant SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50224368(1-(2-chloro-2-phenylethyl)-N-(3-chlorophenyl)-6-(m...)
Affinity DataKi:  600nMAssay Description:Inhibition of human recombinant AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50224368(1-(2-chloro-2-phenylethyl)-N-(3-chlorophenyl)-6-(m...)
Affinity DataKi:  600nMAssay Description:Inhibition of human recombinant SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50224368(1-(2-chloro-2-phenylethyl)-N-(3-chlorophenyl)-6-(m...)
Affinity DataKi:  600nMAssay Description:Inhibition human recombinant Abl using Abtide peptide substrate in presence of [gamma-32P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50224368(1-(2-chloro-2-phenylethyl)-N-(3-chlorophenyl)-6-(m...)
Affinity DataKi:  600nMAssay Description:Inhibition of human wild type full length N-terminal GST/6His-tagged ABL (P118 to S535 residues) expressed in Sf9 cells using abltide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2019
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50224368(1-(2-chloro-2-phenylethyl)-N-(3-chlorophenyl)-6-(m...)
Affinity DataKi:  700nMAssay Description:Inhibition human recombinant cSRC using KVEKIGEGTYGVVYK peptide substrate in presence of [gamma-32P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50224368(1-(2-chloro-2-phenylethyl)-N-(3-chlorophenyl)-6-(m...)
Affinity DataKi:  720nMAssay Description:Inhibition of human wild type full length N-terminal GST/6His-tagged SRC (M1 to L536 residues) expressed in baculovirus infected Sf9 cells using src ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2019
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50224368(1-(2-chloro-2-phenylethyl)-N-(3-chlorophenyl)-6-(m...)
Affinity DataKi:  794nMAssay Description:Inhibition of c-SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed