BDBM50224191 (R)-2-(1-(6-ethoxypyridazin-3-yl)-5-methyl-1H-pyrazol-4-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline::2-[1-(6-ethoxypyridazin-3-yl)-5-methyl-1H-pyrazol-4-yl]-6-[2-(2-(R)-methylpyrrolidin-1-yl)ethyl]quinoline::CHEMBL237394

SMILES CCOc1ccc(nn1)-n1ncc(c1C)-c1ccc2cc(CCN3CCC[C@H]3C)ccc2n1

InChI Key InChIKey=JBAFEJCXHMAIBL-UHFFFAOYSA-N

Data  7 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50224191   

TargetHistamine H3 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224191(2-[1-(6-ethoxypyridazin-3-yl)-5-methyl-1H-pyrazol-...)
Affinity DataEC50:  0.590nMAssay Description:Agonist activity at human histamine H3 receptor expressed in HEK239 cells assessed as reduction of basal [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224191(2-[1-(6-ethoxypyridazin-3-yl)-5-methyl-1H-pyrazol-...)
Affinity DataEC50:  0.740nMAssay Description:Agonist activity at rat histamine H3 receptor expressed in HEK239 cells assessed as reduction of basal [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50224191(2-[1-(6-ethoxypyridazin-3-yl)-5-methyl-1H-pyrazol-...)
Affinity DataIC50: 1.04E+4nMAssay Description:Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224191(2-[1-(6-ethoxypyridazin-3-yl)-5-methyl-1H-pyrazol-...)
Affinity DataKi:  0.190nMAssay Description:Displacement of [3H]-N-alpha methyl histamine from human H3 receptor expressed in C6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224191(2-[1-(6-ethoxypyridazin-3-yl)-5-methyl-1H-pyrazol-...)
Affinity DataKi:  0.190nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224191(2-[1-(6-ethoxypyridazin-3-yl)-5-methyl-1H-pyrazol-...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224191(2-[1-(6-ethoxypyridazin-3-yl)-5-methyl-1H-pyrazol-...)
Affinity DataKi:  0.490nMAssay Description:Displacement of [3H]-N-alpha methyl histamine from rat H3 receptor expressed in C6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224191(2-[1-(6-ethoxypyridazin-3-yl)-5-methyl-1H-pyrazol-...)
Affinity DataKi:  0.490nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from rat cloned histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224191(2-[1-(6-ethoxypyridazin-3-yl)-5-methyl-1H-pyrazol-...)
Affinity DataKi:  1nMAssay Description:Antagonist activity at rat histamine H3 receptor expressed in HEK239 cells assessed as inhibition of RAMH-stimulated [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50224191(2-[1-(6-ethoxypyridazin-3-yl)-5-methyl-1H-pyrazol-...)
Affinity DataKi:  2.60E+3nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed